This gene encodes a RING domain-containing protein that resides in the endoplasmic reticulum (ER) membrane. This protein functions as an E3 ubiquitin ligase and mediates ubiquitination and processing of inositol 1,4,5-trisphosphate (IP3) receptors via the ER-associated protein degradation pathway. It is recruited to the activated IP3 receptors by the ERLIN1/ERLIN2 complex to which it is constitutively bound. Mutations in this gene are associated with autosomal dominant sensory ataxia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| RNF170-20-RE | 20 (40 μL) | 200 μL |  |
Request Pricing |
| RNF170-20-OR | 20 (40 μL) | 200 μL |  |
Request Pricing |
| RNF170-20-GO | 20 (40 μL) | 200 μL |  |
Request Pricing |
| RNF170-20-GR | 20 (40 μL) | 200 μL |  |
Request Pricing |
| RNF170-20-AQ | 20 (40 μL) | 200 μL |  |
Request Pricing |
This gene encodes a RING domain-containing protein that resides in the endoplasmic reticulum (ER) membrane. This protein functions as an E3 ubiquitin ligase and mediates ubiquitination and processing of inositol 1,4,5-trisphosphate (IP3) receptors via the ER-associated protein degradation pathway. It is recruited to the activated IP3 receptors by the ERLIN1/ERLIN2 complex to which it is constitutively bound. Mutations in this gene are associated with autosomal dominant sensory ataxia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012]
Gene Symbol : RNF170
Gene Name : Ring finger protein 170
Chromosome : CHR 8: 428,972,87-428,496,36
Locus : 8p11.21
Alt. Genes : RBM12
Lorem Ipsum is simply dummy text of the printing and typesetting industry.
Lorem Ipsum is simply dummy text of the printing and typesetting industry.