This gene encodes a cytoplasmic protein which specifically colocalizes and interacts with the serine/threonine protein kinase, receptor-interacting protein (RIP). Zinc finger domains of the encoded protein are required for its interaction with RIP and for inhibition of TNF- and IL1-induced NF-kappa B activation pathways. The encoded protein may also function as an E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes and transfers it to substrates. Several alternatively spliced transcript variants have been described for this locus but the full-length natures of only some are known. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| RNF216-20-RE | 20 (40 μL) | 200 μL |  |
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| RNF216-20-OR | 20 (40 μL) | 200 μL |  |
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| RNF216-20-GO | 20 (40 μL) | 200 μL |  |
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| RNF216-20-GR | 20 (40 μL) | 200 μL |  |
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| RNF216-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a cytoplasmic protein which specifically colocalizes and interacts with the serine/threonine protein kinase, receptor-interacting protein (RIP). Zinc finger domains of the encoded protein are required for its interaction with RIP and for inhibition of TNF- and IL1-induced NF-kappa B activation pathways. The encoded protein may also function as an E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes and transfers it to substrates. Several alternatively spliced transcript variants have been described for this locus but the full-length natures of only some are known. [provided by RefSeq, Jul 2008]
Gene Symbol : RNF216
Gene Name : Ring finger protein 216
Chromosome : CHR 7: 578,172,9-562,004,0
Locus : 7p22.1
Alt. Genes : ZNF263
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