This protein encoded by this gene is a member of the RING1-IBR-RING24 (RBR) ubiquitin protein ligase family, and it belongs to a subfamily of these proteins that contain a transmembrane domain. This protein can interact with the HAX1 anti-apoptotic protein via its C-terminal RING finger motif, which suggests a role in apoptosis signaling. It is thought that deregulation of this gene can be a mechanism in leukemogenesis. Mutations in the region encoding the protein GXXXG motif, which appears to be necessary for protein self-association, have been found in human cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| RNF217-20-RE | 20 (40 μL) | 200 μL |  |
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| RNF217-20-OR | 20 (40 μL) | 200 μL |  |
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| RNF217-20-GO | 20 (40 μL) | 200 μL |  |
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| RNF217-20-GR | 20 (40 μL) | 200 μL |  |
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| RNF217-20-AQ | 20 (40 μL) | 200 μL |  |
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This protein encoded by this gene is a member of the RING1-IBR-RING24 (RBR) ubiquitin protein ligase family, and it belongs to a subfamily of these proteins that contain a transmembrane domain. This protein can interact with the HAX1 anti-apoptotic protein via its C-terminal RING finger motif, which suggests a role in apoptosis signaling. It is thought that deregulation of this gene can be a mechanism in leukemogenesis. Mutations in the region encoding the protein GXXXG motif, which appears to be necessary for protein self-association, have been found in human cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]
Gene Symbol : RNF217
Gene Name : Ring finger protein 217
Chromosome : CHR 6: 124,962,406-125,092,633
Locus : 6q22.31
Alt. Genes : FEM1B
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