The protein encoded by this gene contains a RING finger motif and an FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes (E2), including UBE2E1/UBCH6, UBE2E2, and UBE2E3, and may act as an ubiquitin ligase (E3) in the ubiquitination of certain nuclear proteins. This protein is also known to play a role in the DNA damage response and depletion of this protein causes cell growth inhibition and cell cycle arrest. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| RNF8-20-RE | 20 (40 μL) | 200 μL |  |
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| RNF8-20-OR | 20 (40 μL) | 200 μL |  |
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| RNF8-20-GO | 20 (40 μL) | 200 μL |  |
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| RNF8-20-GR | 20 (40 μL) | 200 μL |  |
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| RNF8-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene contains a RING finger motif and an FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes (E2), including UBE2E1/UBCH6, UBE2E2, and UBE2E3, and may act as an ubiquitin ligase (E3) in the ubiquitination of certain nuclear proteins. This protein is also known to play a role in the DNA damage response and depletion of this protein causes cell growth inhibition and cell cycle arrest. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
Gene Symbol : RNF8
Gene Name : Ring finger protein 8
Chromosome : CHR 6: 373,539,71-373,947,37
Locus : 6p21.2
Alt. Genes : SGK2
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