This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ROR1-20-RE | 20 (40 μL) | 200 μL |  |
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| ROR1-20-OR | 20 (40 μL) | 200 μL |  |
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| ROR1-20-GO | 20 (40 μL) | 200 μL |  |
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| ROR1-20-GR | 20 (40 μL) | 200 μL |  |
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| ROR1-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012]
Gene Symbol : ROR1
Gene Name : Receptor tyrosine kinase like orphan receptor 1
Chromosome : CHR 1: 637,740,18-641,814,97
Locus : 1p31.3
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