This gene encodes the small subunit of a p53-inducible ribonucleotide reductase. This heterotetrameric enzyme catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. The product of this reaction is necessary for DNA synthesis. Mutations in this gene have been associated with autosomal recessive mitochondrial DNA depletion syndrome, autosomal dominant progressive external ophthalmoplegia-5, and mitochondrial neurogastrointestinal encephalopathy. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| RRM2B-20-RE | 20 (40 μL) | 200 μL |  |
Request Pricing |
| RRM2B-20-OR | 20 (40 μL) | 200 μL |  |
Request Pricing |
| RRM2B-20-GO | 20 (40 μL) | 200 μL |  |
Request Pricing |
| RRM2B-20-GR | 20 (40 μL) | 200 μL |  |
Request Pricing |
| RRM2B-20-AQ | 20 (40 μL) | 200 μL |  |
Request Pricing |
This gene encodes the small subunit of a p53-inducible ribonucleotide reductase. This heterotetrameric enzyme catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. The product of this reaction is necessary for DNA synthesis. Mutations in this gene have been associated with autosomal recessive mitochondrial DNA depletion syndrome, autosomal dominant progressive external ophthalmoplegia-5, and mitochondrial neurogastrointestinal encephalopathy. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010]
Gene Symbol : RRM2B
Gene Name : Ribonucleotide reductase regulatory TP53 inducible subunit M2B
Chromosome : CHR 8: 102,239,117-102,204,500
Locus : 8q22.3
Alt. Genes : TRAP1
Lorem Ipsum is simply dummy text of the printing and typesetting industry.
Lorem Ipsum is simply dummy text of the printing and typesetting industry.