This gene encodes a secreted activator protein with two cysteine-rich, furin-like domains and one thrombospondin type 1 domain. The encoded protein is a ligand for leucine-rich repeat-containing G-protein coupled receptors (LGR proteins) and positively regulates the Wnt signaling pathway. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| RSPO1-20-RE | 20 (40 μL) | 200 μL |  |
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| RSPO1-20-OR | 20 (40 μL) | 200 μL |  |
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| RSPO1-20-GO | 20 (40 μL) | 200 μL |  |
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| RSPO1-20-GR | 20 (40 μL) | 200 μL |  |
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| RSPO1-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a secreted activator protein with two cysteine-rich, furin-like domains and one thrombospondin type 1 domain. The encoded protein is a ligand for leucine-rich repeat-containing G-protein coupled receptors (LGR proteins) and positively regulates the Wnt signaling pathway. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Gene Symbol : RSPO1
Gene Name : R-spondin 1
Chromosome : CHR 1: 376,349,22-376,113,49
Locus : 1p34.3
Alt. Genes : RAD50
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