This gene encodes a RPIP8, UNC-14, and NESCA domain-containing protein that is required for maintenance of neuronal polarity. In addition, it has been implicated in mediation of gastric cancer cell migration and invasion via interaction with P21-activated kinase-1, which promotes its expression. The encoded protein localizes to F-actin-enriched invadopodia to induce formation of protrusions, thereby facilitating cell migration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| RUFY3-20-RE | 20 (40 μL) | 200 μL |  |
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| RUFY3-20-OR | 20 (40 μL) | 200 μL |  |
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| RUFY3-20-GO | 20 (40 μL) | 200 μL |  |
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| RUFY3-20-GR | 20 (40 μL) | 200 μL |  |
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| RUFY3-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a RPIP8, UNC-14, and NESCA domain-containing protein that is required for maintenance of neuronal polarity. In addition, it has been implicated in mediation of gastric cancer cell migration and invasion via interaction with P21-activated kinase-1, which promotes its expression. The encoded protein localizes to F-actin-enriched invadopodia to induce formation of protrusions, thereby facilitating cell migration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
Gene Symbol : RUFY3
Gene Name : RUN and FYVE domain containing 3
Chromosome : CHR 4: 707,042,03-708,086,21
Locus : 4q13.3
Alt. Genes : LRPPRC
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