This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| RUNX1T1-20-RE | 20 (40 μL) | 200 μL |  |
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| RUNX1T1-20-OR | 20 (40 μL) | 200 μL |  |
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| RUNX1T1-20-GO | 20 (40 μL) | 200 μL |  |
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| RUNX1T1-20-GR | 20 (40 μL) | 200 μL |  |
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| RUNX1T1-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]
Gene Symbol : RUNX1T1
Gene Name : RUNX1 translocation partner 1
Chromosome : CHR 8: 921,033,64-919,549,66
Locus : 8q21.3
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