This gene encodes a scaffold protein involved in the TLR4 signaling pathway that may stimulate cytokine production and endothelial cell migration in response to invading pathogens. The encoded protein has also been described as a potential tumor suppressor that may negatively regulate proliferation, apoptosis, and invasion of cancer cells, and reduced expression of this gene has been observed in multiple human cancers. Mutations in this gene may be associated with abnormal skin pigmentation in human patients. [provided by RefSeq, Oct 2016]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| SASH1-20-RE | 20 (40 μL) | 200 μL |  |
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| SASH1-20-OR | 20 (40 μL) | 200 μL |  |
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| SASH1-20-GO | 20 (40 μL) | 200 μL |  |
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| SASH1-20-GR | 20 (40 μL) | 200 μL |  |
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| SASH1-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a scaffold protein involved in the TLR4 signaling pathway that may stimulate cytokine production and endothelial cell migration in response to invading pathogens. The encoded protein has also been described as a potential tumor suppressor that may negatively regulate proliferation, apoptosis, and invasion of cancer cells, and reduced expression of this gene has been observed in multiple human cancers. Mutations in this gene may be associated with abnormal skin pigmentation in human patients. [provided by RefSeq, Oct 2016]
Gene Symbol : SASH1
Gene Name : SAM and SH3 domain containing 1
Chromosome : CHR 6: 148,193,439-148,552,048
Locus : 6q24.3-q25.1
Alt. Genes : FEM1B
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