Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| SDHB-20-RE | 20 (40 μL) | 200 μL |  |
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| SDHB-20-OR | 20 (40 μL) | 200 μL |  |
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| SDHB-20-GO | 20 (40 μL) | 200 μL |  |
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| SDHB-20-GR | 20 (40 μL) | 200 μL |  |
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| SDHB-20-AQ | 20 (40 μL) | 200 μL |  |
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Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. [provided by RefSeq, Jul 2008]
Gene Symbol : SDHB
Gene Name : Succinate dehydrogenase complex iron sulfur subunit B
Chromosome : CHR 1: 170,541,69-170,187,21
Locus : 1p36.13
Alt. Genes : SGK2
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