The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM, Jun 2009]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| SENP5-20-RE | 20 (40 μL) | 200 μL |  |
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| SENP5-20-OR | 20 (40 μL) | 200 μL |  |
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| SENP5-20-GO | 20 (40 μL) | 200 μL |  |
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| SENP5-20-GR | 20 (40 μL) | 200 μL |  |
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| SENP5-20-AQ | 20 (40 μL) | 200 μL |  |
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The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM, Jun 2009]
Gene Symbol : SENP5
Gene Name : SUMO1/sentrin specific peptidase 5
Chromosome : CHR 3: 196,867,855-196,934,713
Locus : 3q29
Alt. Genes : PREB
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