This locus represents naturally occurring read-through transcription between the neighboring SEPT5 (septin 5) and GP1BB (glycoprotein Ib (platelet), beta polypeptide) genes on chromosome 22. This read-through transcription arises from inefficient use of an imperfect polyA signal in the upstream SEPT5 gene, whereby transcription continues into the GP1BB gene. Alternative splicing results in multiple read-through variants. The read-through transcripts are candidates for nonsense-mediated mRNA decay (NMD), and are therefore unlikely to produce protein products. [provided by RefSeq, Dec 2010]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| SEPT5-GP1BB-20-RE | 20 (40 μL) | 200 μL |  |
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| SEPT5-GP1BB-20-OR | 20 (40 μL) | 200 μL |  |
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| SEPT5-GP1BB-20-GO | 20 (40 μL) | 200 μL |  |
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| SEPT5-GP1BB-20-GR | 20 (40 μL) | 200 μL |  |
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| SEPT5-GP1BB-20-AQ | 20 (40 μL) | 200 μL |  |
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This locus represents naturally occurring read-through transcription between the neighboring SEPT5 (septin 5) and GP1BB (glycoprotein Ib (platelet), beta polypeptide) genes on chromosome 22. This read-through transcription arises from inefficient use of an imperfect polyA signal in the upstream SEPT5 gene, whereby transcription continues into the GP1BB gene. Alternative splicing results in multiple read-through variants. The read-through transcripts are candidates for nonsense-mediated mRNA decay (NMD), and are therefore unlikely to produce protein products. [provided by RefSeq, Dec 2010]
Gene Symbol : SEPT5-GP1BB
Gene Name : SEPT5-GP1BB readthrough
Chromosome : CHR 22: 197,172,19-197,247,73
Locus : 22q11.21
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