This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| SESN1-20-RE | 20 (40 μL) | 200 μL |  |
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| SESN1-20-OR | 20 (40 μL) | 200 μL |  |
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| SESN1-20-GO | 20 (40 μL) | 200 μL |  |
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| SESN1-20-GR | 20 (40 μL) | 200 μL |  |
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| SESN1-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
Gene Symbol : SESN1
Gene Name : Sestrin 1
Chromosome : CHR 6: 109,094,504-108,986,436
Locus : 6q21
Alt. Genes : KIF20A
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