The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt's lymphoma cell lines, it is tyrosine-phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to the Shc/Grb2 pathway. [provided by RefSeq, Jun 2009]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| SH2B2-20-RE | 20 (40 μL) | 200 μL |  |
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| SH2B2-20-OR | 20 (40 μL) | 200 μL |  |
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| SH2B2-20-GO | 20 (40 μL) | 200 μL |  |
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| SH2B2-20-GR | 20 (40 μL) | 200 μL |  |
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| SH2B2-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt's lymphoma cell lines, it is tyrosine-phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to the Shc/Grb2 pathway. [provided by RefSeq, Jun 2009]
Gene Symbol : SH2B2
Gene Name : SH2B adaptor protein 2
Chromosome : CHR 7: 102,284,525-102,321,710
Locus : 7q22.1
Alt. Genes : ZNF263
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