This gene encodes the cytosolic form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one-carbon units for synthesis of methionine, thymidylate, and purines in the cytoplasm. This gene is located within the Smith-Magenis syndrome region on chromosome 17. A pseudogene of this gene is located on the short arm of chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| SHMT1-20-RE | 20 (40 μL) | 200 μL |  |
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| SHMT1-20-OR | 20 (40 μL) | 200 μL |  |
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| SHMT1-20-GO | 20 (40 μL) | 200 μL |  |
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| SHMT1-20-GR | 20 (40 μL) | 200 μL |  |
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| SHMT1-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes the cytosolic form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one-carbon units for synthesis of methionine, thymidylate, and purines in the cytoplasm. This gene is located within the Smith-Magenis syndrome region on chromosome 17. A pseudogene of this gene is located on the short arm of chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Gene Symbol : SHMT1
Gene Name : Serine hydroxymethyltransferase 1
Chromosome : CHR 17: 183,635,62-183,278,59
Locus : 17p11.2
Alt. Genes : LRPPRC
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