This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| SIAH1-20-RE | 20 (40 μL) | 200 μL |  |
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| SIAH1-20-OR | 20 (40 μL) | 200 μL |  |
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| SIAH1-20-GO | 20 (40 μL) | 200 μL |  |
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| SIAH1-20-GR | 20 (40 μL) | 200 μL |  |
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| SIAH1-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
Gene Symbol : SIAH1
Gene Name : Siah E3 ubiquitin protein ligase 1
Chromosome : CHR 16: 484,484,39-483,605,30
Locus : 16q12.1
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