This gene represents a homolog of the Drosophila single-minded (sim) gene, which encodes a transcription factor that is a master regulator of neurogenesis. The encoded protein is ubiquitinated by RING-IBR-RING-type E3 ubiquitin ligases, including the parkin RBR E3 ubiquitin protein ligase. This gene maps within the so-called Down syndrome chromosomal region, and is thus thought to contribute to some specific Down syndrome phenotypes. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| SIM2-20-RE | 20 (40 μL) | 200 μL |  |
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| SIM2-20-OR | 20 (40 μL) | 200 μL |  |
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| SIM2-20-GO | 20 (40 μL) | 200 μL |  |
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| SIM2-20-GR | 20 (40 μL) | 200 μL |  |
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| SIM2-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene represents a homolog of the Drosophila single-minded (sim) gene, which encodes a transcription factor that is a master regulator of neurogenesis. The encoded protein is ubiquitinated by RING-IBR-RING-type E3 ubiquitin ligases, including the parkin RBR E3 ubiquitin protein ligase. This gene maps within the so-called Down syndrome chromosomal region, and is thus thought to contribute to some specific Down syndrome phenotypes. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Gene Symbol : SIM2
Gene Name : Single-minded family bHLH transcription factor 2
Chromosome : CHR 21: 366,991,16-367,502,18
Locus : 21q22.13
Alt. Genes : FEM1B
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