This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| SIRT1-20-RE | 20 (40 μL) | 200 μL |  |
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| SIRT1-20-OR | 20 (40 μL) | 200 μL |  |
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| SIRT1-20-GO | 20 (40 μL) | 200 μL |  |
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| SIRT1-20-GR | 20 (40 μL) | 200 μL |  |
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| SIRT1-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]
Gene Symbol : SIRT1
Gene Name : Sirtuin 1
Chromosome : CHR 10: 678,846,68-679,183,89
Locus : 10q21.3
Alt. Genes : ENAM
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