The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It functions as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| SLAMF6-20-RE | 20 (40 μL) | 200 μL |  |
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| SLAMF6-20-OR | 20 (40 μL) | 200 μL |  |
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| SLAMF6-20-GO | 20 (40 μL) | 200 μL |  |
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| SLAMF6-20-GR | 20 (40 μL) | 200 μL |  |
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| SLAMF6-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It functions as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010]
Gene Symbol : SLAMF6
Gene Name : SLAM family member 6
Chromosome : CHR 1: 160,523,267-160,485,029
Locus : 1q23.2-q23.3
Alt. Genes : MPHOSPH6
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