This gene encodes a renal thiazide-sensitive sodium-chloride cotransporter that is important for electrolyte homeostasis. This cotransporter mediates sodium and chloride reabsorption in the distal convoluted tubule. Mutations in this gene cause Gitelman syndrome, a disease similar to Bartter's syndrome, that is characterized by hypokalemic alkalosis combined with hypomagnesemia, low urinary calcium, and increased renin activity associated with normal blood pressure. This cotransporter is the target for thiazide diuretics that are used for treating high blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| SLC12A3-20-RE | 20 (40 μL) | 200 μL |  |
Request Pricing |
| SLC12A3-20-OR | 20 (40 μL) | 200 μL |  |
Request Pricing |
| SLC12A3-20-GO | 20 (40 μL) | 200 μL |  |
Request Pricing |
| SLC12A3-20-GR | 20 (40 μL) | 200 μL |  |
Request Pricing |
| SLC12A3-20-AQ | 20 (40 μL) | 200 μL |  |
Request Pricing |
This gene encodes a renal thiazide-sensitive sodium-chloride cotransporter that is important for electrolyte homeostasis. This cotransporter mediates sodium and chloride reabsorption in the distal convoluted tubule. Mutations in this gene cause Gitelman syndrome, a disease similar to Bartter's syndrome, that is characterized by hypokalemic alkalosis combined with hypomagnesemia, low urinary calcium, and increased renin activity associated with normal blood pressure. This cotransporter is the target for thiazide diuretics that are used for treating high blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Symbol : SLC12A3
Gene Name : Solute carrier family 12 member 3
Chromosome : CHR 16: 568,652,06-569,158,49
Locus : 16q13
Alt. Genes : PREB
Lorem Ipsum is simply dummy text of the printing and typesetting industry.
Lorem Ipsum is simply dummy text of the printing and typesetting industry.