This gene encodes a member of the the SLC39A family of divalent metal transporters that mediates the cellular uptake of manganese, zinc, iron, and cadmium. The encoded protein contains eight transmembrane domains, a histidine-rich motif, and a metalloprotease motif, and is expressed on the plasma membrane and the endocytic vesicle membrane. It is an important transporter of nontransferrin-bound iron and a critical regulator of manganese homeostasis. Naturally occurring mutations in this gene are associated with neurodegeneration with brain iron accumulation and early-onset parkinsonism-dystonia with hypermanganesemia. [provided by RefSeq, May 2017]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| SLC39A14-20-RE | 20 (40 μL) | 200 μL |  |
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| SLC39A14-20-OR | 20 (40 μL) | 200 μL |  |
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| SLC39A14-20-GO | 20 (40 μL) | 200 μL |  |
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| SLC39A14-20-GR | 20 (40 μL) | 200 μL |  |
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| SLC39A14-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a member of the the SLC39A family of divalent metal transporters that mediates the cellular uptake of manganese, zinc, iron, and cadmium. The encoded protein contains eight transmembrane domains, a histidine-rich motif, and a metalloprotease motif, and is expressed on the plasma membrane and the endocytic vesicle membrane. It is an important transporter of nontransferrin-bound iron and a critical regulator of manganese homeostasis. Naturally occurring mutations in this gene are associated with neurodegeneration with brain iron accumulation and early-onset parkinsonism-dystonia with hypermanganesemia. [provided by RefSeq, May 2017]
Gene Symbol : SLC39A14
Gene Name : Solute carrier family 39 member 14
Chromosome : CHR 8: 223,672,48-224,341,28
Locus : 8p21.3
Alt. Genes : ZNF263
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