The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| SMAD7-20-RE | 20 (40 μL) | 200 μL |  |
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| SMAD7-20-OR | 20 (40 μL) | 200 μL |  |
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| SMAD7-20-GO | 20 (40 μL) | 200 μL |  |
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| SMAD7-20-GR | 20 (40 μL) | 200 μL |  |
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| SMAD7-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Gene Symbol : SMAD7
Gene Name : SMAD family member 7
Chromosome : CHR 18: 489,507,10-489,198,52
Locus : 18q21.1
Alt. Genes : FEM1B
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