The protein encoded by this gene is part of the large ATP-dependent chromatin remodeling complex SWI/SNF, which is required for transcriptional activation of genes normally repressed by chromatin. The encoded protein, either alone or when in the SWI/SNF complex, can bind to 4-way junction DNA, which is thought to mimic the topology of DNA as it enters or exits the nucleosome. The protein contains a DNA-binding HMG domain, but disruption of this domain does not abolish the DNA-binding or nucleosome-displacement activities of the SWI/SNF complex. Unlike most of the SWI/SNF complex proteins, this protein has no yeast counterpart. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| SMARCE1-20-RE | 20 (40 μL) | 200 μL |  |
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| SMARCE1-20-OR | 20 (40 μL) | 200 μL |  |
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| SMARCE1-20-GO | 20 (40 μL) | 200 μL |  |
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| SMARCE1-20-GR | 20 (40 μL) | 200 μL |  |
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| SMARCE1-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene is part of the large ATP-dependent chromatin remodeling complex SWI/SNF, which is required for transcriptional activation of genes normally repressed by chromatin. The encoded protein, either alone or when in the SWI/SNF complex, can bind to 4-way junction DNA, which is thought to mimic the topology of DNA as it enters or exits the nucleosome. The protein contains a DNA-binding HMG domain, but disruption of this domain does not abolish the DNA-binding or nucleosome-displacement activities of the SWI/SNF complex. Unlike most of the SWI/SNF complex proteins, this protein has no yeast counterpart. [provided by RefSeq, Jul 2008]
Gene Symbol : SMARCE1
Gene Name : SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
Chromosome : CHR 17: 406,478,50-406,277,19
Locus : 17q21.2
Alt. Genes : FEM1B
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