This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD); a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2011]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| SMG7-20-RE | 20 (40 μL) | 200 μL |  |
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| SMG7-20-OR | 20 (40 μL) | 200 μL |  |
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| SMG7-20-GO | 20 (40 μL) | 200 μL |  |
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| SMG7-20-GR | 20 (40 μL) | 200 μL |  |
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| SMG7-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD); a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2011]
Gene Symbol : SMG7
Gene Name : SMG7, nonsense mediated mRNA decay factor
Chromosome : CHR 1: 183,471,961-183,554,192
Locus : 1q25.3
Alt. Genes : LRPPRC
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