The protein encoded by this gene is a sphingomyelinase that catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide. This gene is activated by DNA damage, cellular stress, and tumor necrosis factor, but it is downregulated by wild-type p53. The encoded protein localizes to the endoplasmic reticulum and Golgi network. [provided by RefSeq, Mar 2017]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| SMPD4-20-RE | 20 (40 μL) | 200 μL |  |
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| SMPD4-20-OR | 20 (40 μL) | 200 μL |  |
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| SMPD4-20-GO | 20 (40 μL) | 200 μL |  |
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| SMPD4-20-GR | 20 (40 μL) | 200 μL |  |
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| SMPD4-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene is a sphingomyelinase that catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide. This gene is activated by DNA damage, cellular stress, and tumor necrosis factor, but it is downregulated by wild-type p53. The encoded protein localizes to the endoplasmic reticulum and Golgi network. [provided by RefSeq, Mar 2017]
Gene Symbol : SMPD4
Gene Name : Sphingomyelin phosphodiesterase 4
Chromosome : CHR 2: 130,182,749-130,151,391
Locus : 2q21.1
Alt. Genes : AKAP9
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