Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| SNCA-20-RE | 20 (40 μL) | 200 μL |  |
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| SNCA-20-OR | 20 (40 μL) | 200 μL |  |
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| SNCA-20-GO | 20 (40 μL) | 200 μL |  |
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| SNCA-20-GR | 20 (40 μL) | 200 μL |  |
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| SNCA-20-AQ | 20 (40 μL) | 200 μL |  |
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Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]
Gene Symbol : SNCA
Gene Name : Synuclein alpha
Chromosome : CHR 4: 898,383,23-897,240,98
Locus : 4q22.1
Alt. Genes : FARP1
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