Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| SOST-20-RE | 20 (40 μL) | 200 μL |  |
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| SOST-20-OR | 20 (40 μL) | 200 μL |  |
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| SOST-20-GO | 20 (40 μL) | 200 μL |  |
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| SOST-20-GR | 20 (40 μL) | 200 μL |  |
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| SOST-20-AQ | 20 (40 μL) | 200 μL |  |
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Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease. [provided by RefSeq, Jul 2008]
Gene Symbol : SOST
Gene Name : Sclerostin
Chromosome : CHR 17: 437,587,87-437,537,30
Locus : 17q21.31
Alt. Genes : KIF20A
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