This gene encodes a subnuclear organelle and major component of the PML (promyelocytic leukemia)-SP100 nuclear bodies. PML and SP100 are covalently modified by the SUMO-1 modifier, which is considered crucial to nuclear body interactions. The encoded protein binds heterochromatin proteins and is thought to play a role in tumorigenesis, immunity, and gene regulation. Alternatively spliced variants have been identified for this gene; one of which encodes a high-mobility group protein. [provided by RefSeq, Aug 2011]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| SP100-20-RE | 20 (40 μL) | 200 μL |  |
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| SP100-20-OR | 20 (40 μL) | 200 μL |  |
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| SP100-20-GO | 20 (40 μL) | 200 μL |  |
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| SP100-20-GR | 20 (40 μL) | 200 μL |  |
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| SP100-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a subnuclear organelle and major component of the PML (promyelocytic leukemia)-SP100 nuclear bodies. PML and SP100 are covalently modified by the SUMO-1 modifier, which is considered crucial to nuclear body interactions. The encoded protein binds heterochromatin proteins and is thought to play a role in tumorigenesis, immunity, and gene regulation. Alternatively spliced variants have been identified for this gene; one of which encodes a high-mobility group protein. [provided by RefSeq, Aug 2011]
Gene Symbol : SP100
Gene Name : SP100 nuclear antigen
Chromosome : CHR 2: 230,416,155-230,545,601
Locus : 2q37.1
Alt. Genes : KATNB1
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