The protein encoded by this gene binds to the hydrophobic C-terminal amino acids of CD4 which are involved in repression of T cell activation. The interaction with CD4 is mediated by the noncatalytic alpha/beta hydrolase fold domain of this protein. It is thus proposed that this gene product modulates the stimulatory activity of CD4. Mutations in this gene are associated with autosomal recessive spastic paraplegia 21 (SPG21), also known as mast syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| SPG21-20-RE | 20 (40 μL) | 200 μL |  |
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| SPG21-20-OR | 20 (40 μL) | 200 μL |  |
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| SPG21-20-GO | 20 (40 μL) | 200 μL |  |
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| SPG21-20-GR | 20 (40 μL) | 200 μL |  |
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| SPG21-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene binds to the hydrophobic C-terminal amino acids of CD4 which are involved in repression of T cell activation. The interaction with CD4 is mediated by the noncatalytic alpha/beta hydrolase fold domain of this protein. It is thus proposed that this gene product modulates the stimulatory activity of CD4. Mutations in this gene are associated with autosomal recessive spastic paraplegia 21 (SPG21), also known as mast syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
Gene Symbol : SPG21
Gene Name : SPG21, maspardin
Chromosome : CHR 15: 649,899,45-649,630,20
Locus : 15q22.31
Alt. Genes : HIPK3
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