This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| SPHK2-20-RE | 20 (40 μL) | 200 μL |  |
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| SPHK2-20-OR | 20 (40 μL) | 200 μL |  |
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| SPHK2-20-GO | 20 (40 μL) | 200 μL |  |
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| SPHK2-20-GR | 20 (40 μL) | 200 μL |  |
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| SPHK2-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]
Gene Symbol : SPHK2
Gene Name : Sphingosine kinase 2
Chromosome : CHR 19: 486,192,90-486,304,06
Locus : 19q13.33
Alt. Genes : EBI3
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