This gene encodes the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex. The encoded protein is an ATPase that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. It can function as a transcriptional activator in Notch-mediated, CREB-mediated and steroid receptor-mediated transcription. Mutations in this gene cause Floating-Harbor syndrome, a rare disorder characterized by short stature, language deficits and dysmorphic facial features. [provided by RefSeq, Feb 2012]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| SRCAP-20-RE | 20 (40 μL) | 200 μL |  |
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| SRCAP-20-OR | 20 (40 μL) | 200 μL |  |
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| SRCAP-20-GO | 20 (40 μL) | 200 μL |  |
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| SRCAP-20-GR | 20 (40 μL) | 200 μL |  |
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| SRCAP-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex. The encoded protein is an ATPase that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. It can function as a transcriptional activator in Notch-mediated, CREB-mediated and steroid receptor-mediated transcription. Mutations in this gene cause Floating-Harbor syndrome, a rare disorder characterized by short stature, language deficits and dysmorphic facial features. [provided by RefSeq, Feb 2012]
Gene Symbol : SRCAP
Gene Name : Snf2 related CREBBP activator protein
Chromosome : CHR 16: 306,991,40-307,401,28
Locus : 16p11.2
Alt. Genes : OPTN
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