The protein encoded by this gene belongs to the slingshot homolog (SSH) family of phosphatases, which regulate actin filament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Cofilin is inactivated by kinases such as LIM domain kinase-1 (LIMK1), which may also be dephosphorylated and inactivated by SSH proteins. The SSH family thus appears to play a role in actin dynamics by reactivating cofilin proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| SSH1-20-RE | 20 (40 μL) | 200 μL |  |
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| SSH1-20-OR | 20 (40 μL) | 200 μL |  |
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| SSH1-20-GO | 20 (40 μL) | 200 μL |  |
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| SSH1-20-GR | 20 (40 μL) | 200 μL |  |
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| SSH1-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene belongs to the slingshot homolog (SSH) family of phosphatases, which regulate actin filament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Cofilin is inactivated by kinases such as LIM domain kinase-1 (LIMK1), which may also be dephosphorylated and inactivated by SSH proteins. The SSH family thus appears to play a role in actin dynamics by reactivating cofilin proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Gene Symbol : SSH1
Gene Name : Slingshot protein phosphatase 1
Chromosome : CHR 12: 108,857,605-108,782,689
Locus : 12q24.11
Alt. Genes : KIF20A
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