This gene was identified by its ability to suppress the tumorigenicity of Hela cells in nude mice. The protein encoded by this gene contains a C-terminal region that shares similarity with the Rab 3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain of c-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype in cells. Three alternatively spliced transcript variants of this gene encoding distinct isoforms are identified. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ST5-20-RE | 20 (40 μL) | 200 μL |  |
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| ST5-20-OR | 20 (40 μL) | 200 μL |  |
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| ST5-20-GO | 20 (40 μL) | 200 μL |  |
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| ST5-20-GR | 20 (40 μL) | 200 μL |  |
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| ST5-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene was identified by its ability to suppress the tumorigenicity of Hela cells in nude mice. The protein encoded by this gene contains a C-terminal region that shares similarity with the Rab 3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain of c-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype in cells. Three alternatively spliced transcript variants of this gene encoding distinct isoforms are identified. [provided by RefSeq, Jul 2008]
Gene Symbol : ST5
Gene Name : Suppression of tumorigenicity 5
Chromosome : CHR 11: 891,095,0-869,335,1
Locus : 11p15.4
Alt. Genes : SGK2
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