The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| STAT4-20-RE | 20 (40 μL) | 200 μL |  |
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| STAT4-20-OR | 20 (40 μL) | 200 μL |  |
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| STAT4-20-GO | 20 (40 μL) | 200 μL |  |
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| STAT4-20-GR | 20 (40 μL) | 200 μL |  |
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| STAT4-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011]
Gene Symbol : STAT4
Gene Name : Signal transducer and activator of transcription 4
Chromosome : CHR 2: 191,172,683-191,029,575
Locus : 2q32.2-q32.3
Alt. Genes : PREB
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