The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| STK4-20-RE | 20 (40 μL) | 200 μL |  |
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| STK4-20-OR | 20 (40 μL) | 200 μL |  |
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| STK4-20-GO | 20 (40 μL) | 200 μL |  |
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| STK4-20-GR | 20 (40 μL) | 200 μL |  |
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| STK4-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process. [provided by RefSeq, Jul 2008]
Gene Symbol : STK4
Gene Name : Serine/threonine kinase 4
Chromosome : CHR 20: 449,664,73-450,799,76
Locus : 20q13.12
Alt. Genes : LINC01587
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