The catalytic sites of sulfatases are only active if they contain a unique amino acid, C-alpha-formylglycine (FGly). The FGly residue is posttranslationally generated from a cysteine by enzymes with FGly-generating activity. The gene described in this record is a member of the sulfatase-modifying factor family and encodes a protein with a DUF323 domain that localizes to the lumen of the endoplasmic reticulum. This protein has low levels of FGly-generating activity but can heterodimerize with another family member - a protein with high levels of FGly-generating activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| SUMF2-20-RE | 20 (40 μL) | 200 μL |  |
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| SUMF2-20-OR | 20 (40 μL) | 200 μL |  |
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| SUMF2-20-GO | 20 (40 μL) | 200 μL |  |
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| SUMF2-20-GR | 20 (40 μL) | 200 μL |  |
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| SUMF2-20-AQ | 20 (40 μL) | 200 μL |  |
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The catalytic sites of sulfatases are only active if they contain a unique amino acid, C-alpha-formylglycine (FGly). The FGly residue is posttranslationally generated from a cysteine by enzymes with FGly-generating activity. The gene described in this record is a member of the sulfatase-modifying factor family and encodes a protein with a DUF323 domain that localizes to the lumen of the endoplasmic reticulum. This protein has low levels of FGly-generating activity but can heterodimerize with another family member - a protein with high levels of FGly-generating activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Symbol : SUMF2
Gene Name : Sulfatase modifying factor 2
Chromosome : CHR 7: 560,640,06-560,806,71
Locus : 7p11.2
Alt. Genes : PREB
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