SUN1 (MIM 607723) and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a 'bridge' across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KASH domain of nesprins (e.g., SYNE1; MIM 608441) located in the outer nuclear membrane (ONM). The LINC complex provides a direct connection between the nuclear lamina and the cytoskeleton, which contributes to nuclear positioning and cellular rigidity (summary by Haque et al., 2010 [PubMed 19933576]).[supplied by OMIM, Nov 2010]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| SUN2-20-RE | 20 (40 μL) | 200 μL |  |
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| SUN2-20-OR | 20 (40 μL) | 200 μL |  |
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| SUN2-20-GO | 20 (40 μL) | 200 μL |  |
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| SUN2-20-GR | 20 (40 μL) | 200 μL |  |
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| SUN2-20-AQ | 20 (40 μL) | 200 μL |  |
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SUN1 (MIM 607723) and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a 'bridge' across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KASH domain of nesprins (e.g., SYNE1; MIM 608441) located in the outer nuclear membrane (ONM). The LINC complex provides a direct connection between the nuclear lamina and the cytoskeleton, which contributes to nuclear positioning and cellular rigidity (summary by Haque et al., 2010 [PubMed 19933576]).[supplied by OMIM, Nov 2010]
Gene Symbol : SUN2
Gene Name : Sad1 and UNC84 domain containing 2
Chromosome : CHR 22: 387,560,18-387,347,13
Locus : 22q13.1
Alt. Genes : LINC01587
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