This gene encodes a protein localized to the inner mitochondrial membrane and thought to be involved in the biogenesis of the cytochrome c oxidase complex. The protein is a member of the SURF1 family, which includes the related yeast protein SHY1 and rickettsial protein RP733. The gene is located in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity, where it shares a bidirectional promoter with SURF2 on the opposite strand. Defects in this gene are a cause of Leigh syndrome, a severe neurological disorder that is commonly associated with systemic cytochrome c oxidase deficiency. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| SURF1-20-RE | 20 (40 μL) | 200 μL |  |
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| SURF1-20-OR | 20 (40 μL) | 200 μL |  |
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| SURF1-20-GO | 20 (40 μL) | 200 μL |  |
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| SURF1-20-GR | 20 (40 μL) | 200 μL |  |
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| SURF1-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a protein localized to the inner mitochondrial membrane and thought to be involved in the biogenesis of the cytochrome c oxidase complex. The protein is a member of the SURF1 family, which includes the related yeast protein SHY1 and rickettsial protein RP733. The gene is located in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity, where it shares a bidirectional promoter with SURF2 on the opposite strand. Defects in this gene are a cause of Leigh syndrome, a severe neurological disorder that is commonly associated with systemic cytochrome c oxidase deficiency. [provided by RefSeq, Jul 2008]
Gene Symbol : SURF1
Gene Name : SURF1, cytochrome c oxidase assembly factor
Chromosome : CHR 9: 133,356,484-133,351,804
Locus : 9q34.2
Alt. Genes : FARP1
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