HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TARDBP-20-RE | 20 (40 μL) | 200 μL |  |
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| TARDBP-20-OR | 20 (40 μL) | 200 μL |  |
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| TARDBP-20-GO | 20 (40 μL) | 200 μL |  |
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| TARDBP-20-GR | 20 (40 μL) | 200 μL |  |
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| TARDBP-20-AQ | 20 (40 μL) | 200 μL |  |
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HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [provided by RefSeq, Jul 2008]
Gene Symbol : TARDBP
Gene Name : TAR DNA binding protein
Chromosome : CHR 1: 110,126,21-110,305,27
Locus : 1p36.22
Alt. Genes : ENAM
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