This gene is a member of the WD40 repeat-containing gene family and shares sequence similarity with transducin (beta)-like 1X-linked (TBL1X). The protein encoded by this gene is thought to be a component of both nuclear receptor corepressor (N-CoR) and histone deacetylase 3 (HDAC 3) complexes, and is required for transcriptional activation by a variety of transcription factors. Mutations in these gene have been associated with some autism spectrum disorders, and one finding suggests that haploinsufficiency of this gene may be a cause of intellectual disability with dysmorphism. Mutations in this gene as well as recurrent translocations involving this gene have also been observed in some tumors. [provided by RefSeq, Mar 2016]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TBL1XR1-20-RE | 20 (40 μL) | 200 μL |  |
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| TBL1XR1-20-OR | 20 (40 μL) | 200 μL |  |
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| TBL1XR1-20-GO | 20 (40 μL) | 200 μL |  |
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| TBL1XR1-20-GR | 20 (40 μL) | 200 μL |  |
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| TBL1XR1-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene is a member of the WD40 repeat-containing gene family and shares sequence similarity with transducin (beta)-like 1X-linked (TBL1X). The protein encoded by this gene is thought to be a component of both nuclear receptor corepressor (N-CoR) and histone deacetylase 3 (HDAC 3) complexes, and is required for transcriptional activation by a variety of transcription factors. Mutations in these gene have been associated with some autism spectrum disorders, and one finding suggests that haploinsufficiency of this gene may be a cause of intellectual disability with dysmorphism. Mutations in this gene as well as recurrent translocations involving this gene have also been observed in some tumors. [provided by RefSeq, Mar 2016]
Gene Symbol : TBL1XR1
Gene Name : Transducin beta like 1 X-linked receptor 1
Chromosome : CHR 3: 177,197,356-177,019,354
Locus : 3q26.32
Alt. Genes : ZNF263
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