This gene encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes. The encoded protein may also play a role in the NF-kappaB and ERK1/2 signaling pathways. Expression of this gene may play a role in the proliferation of several types of cancer including thyroid cancer, breast cancer and hematological malignancies. [provided by RefSeq, Nov 2011]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TCIM-20-RE | 20 (40 μL) | 200 μL |  |
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| TCIM-20-OR | 20 (40 μL) | 200 μL |  |
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| TCIM-20-GO | 20 (40 μL) | 200 μL |  |
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| TCIM-20-GR | 20 (40 μL) | 200 μL |  |
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| TCIM-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes. The encoded protein may also play a role in the NF-kappaB and ERK1/2 signaling pathways. Expression of this gene may play a role in the proliferation of several types of cancer including thyroid cancer, breast cancer and hematological malignancies. [provided by RefSeq, Nov 2011]
Gene Symbol : TCIM
Gene Name : Transcriptional and immune response regulator
Chromosome : CHR 8: 401,534,67-401,553,07
Locus : 8p11.21
Alt. Genes : FEM1B
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