Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TCL1A-20-RE | 20 (40 μL) | 200 μL |  |
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| TCL1A-20-OR | 20 (40 μL) | 200 μL |  |
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| TCL1A-20-GO | 20 (40 μL) | 200 μL |  |
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| TCL1A-20-GR | 20 (40 μL) | 200 μL |  |
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| TCL1A-20-AQ | 20 (40 μL) | 200 μL |  |
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Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010]
Gene Symbol : TCL1A
Gene Name : T-cell leukemia/lymphoma 1A
Chromosome : CHR 14: 957,141,95-956,941,59
Locus : 14q32.13
Alt. Genes : SLC25A13
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