The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). [provided by RefSeq, Aug 2016]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TDP1-20-RE | 20 (40 μL) | 200 μL |  |
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| TDP1-20-OR | 20 (40 μL) | 200 μL |  |
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| TDP1-20-GO | 20 (40 μL) | 200 μL |  |
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| TDP1-20-GR | 20 (40 μL) | 200 μL |  |
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| TDP1-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). [provided by RefSeq, Aug 2016]
Gene Symbol : TDP1
Gene Name : Tyrosyl-DNA phosphodiesterase 1
Chromosome : CHR 14: 899,549,34-900,447,63
Locus : 14q32.11
Alt. Genes : FEM1B
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