This gene encodes a protein component of the spliceosome that promotes the release of the lariat-intron during late-stage splicing through the recruitment of a pre-mRNA splicing factor called DEAH-box helicase 15. The encoded protein contains a G-patch domain, a hallmark of RNA-processing proteins, that binds DEAH-box helicase 15. This protein contains an atypical nuclear localization sequence as well as a nuclear speckle-targeting sequence, enabling it to localize to distinct speckled regions within the cell nucleus. Polymorphisms in this gene are associated with dental caries suggesting a role in amelogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TFIP11-20-RE | 20 (40 μL) | 200 μL |  |
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| TFIP11-20-OR | 20 (40 μL) | 200 μL |  |
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| TFIP11-20-GO | 20 (40 μL) | 200 μL |  |
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| TFIP11-20-GR | 20 (40 μL) | 200 μL |  |
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| TFIP11-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a protein component of the spliceosome that promotes the release of the lariat-intron during late-stage splicing through the recruitment of a pre-mRNA splicing factor called DEAH-box helicase 15. The encoded protein contains a G-patch domain, a hallmark of RNA-processing proteins, that binds DEAH-box helicase 15. This protein contains an atypical nuclear localization sequence as well as a nuclear speckle-targeting sequence, enabling it to localize to distinct speckled regions within the cell nucleus. Polymorphisms in this gene are associated with dental caries suggesting a role in amelogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]
Gene Symbol : TFIP11
Gene Name : Tuftelin interacting protein 11
Chromosome : CHR 22: 265,124,95-264,919,26
Locus : 22q12.1
Alt. Genes : HIPK3
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