This genomic region represents the human ortholog of the mouse T helper type 2 (Th2) cytokine locus control region (LCR), which in transgenic assays can confer copy number-dependent, position-independent expression on the mouse interleukin 4 (Il4), interleukin 13 (Il13) and interleukin 5 (Il5) genes during differentiation of naive CD4+ T cells along the Th2 pathway. This region overlaps the 3' end of the RAD50 gene, which is located between the IL13 and IL5 genes, and it also overlaps an opposite strand gene (TH2LCRR) that produces long non-coding RNAs. This region is characterized by three conserved DNase I hypersensitive sites (RHS5-RHS7), which bind transcription factors and are thought to regulate the IL4, IL5 and IL13 genes. The human RHS7 region has been shown to act as an enhancer, and it also includes a sub-fragment with silencing activity. A polymorphism in RHS7 is associated with human atopic diseases, and it can affect protein binding and the regulatory potential of this element. [provided by RefSeq, Aug 2015]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TH2-LCR-20-RE | 20 (40 μL) | 200 μL |  |
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| TH2-LCR-20-OR | 20 (40 μL) | 200 μL |  |
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| TH2-LCR-20-GO | 20 (40 μL) | 200 μL |  |
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| TH2-LCR-20-GR | 20 (40 μL) | 200 μL |  |
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| TH2-LCR-20-AQ | 20 (40 μL) | 200 μL |  |
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This genomic region represents the human ortholog of the mouse T helper type 2 (Th2) cytokine locus control region (LCR), which in transgenic assays can confer copy number-dependent, position-independent expression on the mouse interleukin 4 (Il4), interleukin 13 (Il13) and interleukin 5 (Il5) genes during differentiation of naive CD4+ T cells along the Th2 pathway. This region overlaps the 3' end of the RAD50 gene, which is located between the IL13 and IL5 genes, and it also overlaps an opposite strand gene (TH2LCRR) that produces long non-coding RNAs. This region is characterized by three conserved DNase I hypersensitive sites (RHS5-RHS7), which bind transcription factors and are thought to regulate the IL4, IL5 and IL13 genes. The human RHS7 region has been shown to act as an enhancer, and it also includes a sub-fragment with silencing activity. A polymorphism in RHS7 is associated with human atopic diseases, and it can affect protein binding and the regulatory potential of this element. [provided by RefSeq, Aug 2015]
Gene Symbol : TH2-LCR
Gene Name : Th2 cytokine locus control region
Chromosome :
Locus : 5q31
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