Protein kinase B (PKB) is a major downstream target of receptor tyrosine kinases that signal via phosphatidylinositol 3-kinase. Upon cell stimulation, PKB is translocated to the plasma membrane, where it is phosphorylated in the C-terminal regulatory domain. The protein encoded by this gene negatively regulates PKB activity by inhibiting phosphorylation. Transcription of this gene is commonly downregulated in glioblastomas. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| THEM4-20-RE | 20 (40 μL) | 200 μL |  |
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| THEM4-20-OR | 20 (40 μL) | 200 μL |  |
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| THEM4-20-GO | 20 (40 μL) | 200 μL |  |
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| THEM4-20-GR | 20 (40 μL) | 200 μL |  |
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| THEM4-20-AQ | 20 (40 μL) | 200 μL |  |
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Protein kinase B (PKB) is a major downstream target of receptor tyrosine kinases that signal via phosphatidylinositol 3-kinase. Upon cell stimulation, PKB is translocated to the plasma membrane, where it is phosphorylated in the C-terminal regulatory domain. The protein encoded by this gene negatively regulates PKB activity by inhibiting phosphorylation. Transcription of this gene is commonly downregulated in glioblastomas. [provided by RefSeq, Jul 2008]
Gene Symbol : THEM4
Gene Name : Thioesterase superfamily member 4
Chromosome : CHR 1: 151,909,884-151,870,865
Locus : 1q21.3
Alt. Genes : ATP6AP2
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