The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TIRAP-20-RE | 20 (40 μL) | 200 μL |  |
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| TIRAP-20-OR | 20 (40 μL) | 200 μL |  |
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| TIRAP-20-GO | 20 (40 μL) | 200 μL |  |
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| TIRAP-20-GR | 20 (40 μL) | 200 μL |  |
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| TIRAP-20-AQ | 20 (40 μL) | 200 μL |  |
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The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]
Gene Symbol : TIRAP
Gene Name : TIR domain containing adaptor protein
Chromosome : CHR 11: 126,281,267-126,294,932
Locus : 11q24.2
Alt. Genes : LRPPRC
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