This gene encodes a member of the Groucho/ transducin-like Enhancer of split family of transcriptional co-repressors. The encoded protein is a component of the mammalian subcortical maternal complex, which is required for preimplantation development. In mouse, knock out of this gene results in cleavage-stage embryonic arrest resulting from defective cytoplasmic F-actin meshwork formation and asymmetric cell division. In human, an allelic variant in this gene is associated with preimplantation embryonic lethality. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TLE6-20-RE | 20 (40 μL) | 200 μL |  |
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| TLE6-20-OR | 20 (40 μL) | 200 μL |  |
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| TLE6-20-GO | 20 (40 μL) | 200 μL |  |
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| TLE6-20-GR | 20 (40 μL) | 200 μL |  |
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| TLE6-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a member of the Groucho/ transducin-like Enhancer of split family of transcriptional co-repressors. The encoded protein is a component of the mammalian subcortical maternal complex, which is required for preimplantation development. In mouse, knock out of this gene results in cleavage-stage embryonic arrest resulting from defective cytoplasmic F-actin meshwork formation and asymmetric cell division. In human, an allelic variant in this gene is associated with preimplantation embryonic lethality. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
Gene Symbol : TLE6
Gene Name : Transducin like enhancer of split 6
Chromosome : CHR 19: 297,740,9-299,518,3
Locus : 19p13.3
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