This gene encodes an astacin-like, zinc-dependent, metalloprotease that belongs to the peptidase M12A family. This protease processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Studies in mice suggest that this gene plays multiple roles in the development of mammalian heart, and is essential for the formation of the interventricular septum. Allelic variants of this gene are associated with atrial septal defect type 6. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TLL1-20-RE | 20 (40 μL) | 200 μL |  |
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| TLL1-20-OR | 20 (40 μL) | 200 μL |  |
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| TLL1-20-GO | 20 (40 μL) | 200 μL |  |
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| TLL1-20-GR | 20 (40 μL) | 200 μL |  |
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| TLL1-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes an astacin-like, zinc-dependent, metalloprotease that belongs to the peptidase M12A family. This protease processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Studies in mice suggest that this gene plays multiple roles in the development of mammalian heart, and is essential for the formation of the interventricular septum. Allelic variants of this gene are associated with atrial septal defect type 6. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
Gene Symbol : TLL1
Gene Name : Tolloid like 1
Chromosome : CHR 4: 165,873,237-166,105,177
Locus : 4q32.3
Alt. Genes : TRAP1
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